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H383 Primary Glaucoma

Background

Primary open angle glaucoma is a leading cause of blindness in dogs. Elevated intraocular pressure is the most important risk factor. Increased resistance to outflow of aqueous humor through the trabecular meshwork causes elevated intraocular pressure, but the specific mechanisms are unknown.

Test specific information

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Age

‘Late onset’ – This phrase indicates, that the symptoms of the disease can be detected at a later ages. ‘Late onset’ is the opposite of ‘early onset’, in which symptoms may be present at younger ages. The phrases are used because the mutation causing ´late onset´ symptoms may be different compared to the mutations causing ´early onset´ symptoms.

Throughput

Normally the result can be expected within 10 working days. This turn-around-time starts when both the sample and the fully filled-out and signed submission form have been received.

Location of disease or trait

This disease mainly affects vision, and may result in blindness.

Breed dependence

This DNA test is available for the following breeds: Norwegian Elkhound. Additional information is available in the Frequently Asked Questions (FAQ).

Sample type

For this DNA test we accept the following materials: Blood EDTA, Blood Heparin, Semen, Swab, Tissue. Please contact Dr. Van Haeringen Laboratorium if you wish to submit other material as listed.

Result

An animal can be free and has in that situation two healthy alleles. When used in breeding this animal will not become ill due to the disease. It cannot spread the disease in the population.

An animal can be carrier and has in that situation one healthy and one disease allele. When used in breeding 50 percent of the offspring will receive the disease allele. Carriers will not become ill.

An animal can be affected and has in that situation two disease alleles. When used in breeding all offspring will also receive the disease allele. Affected will become ill.

Inheritance

This genetic factor is inherited in an autosomal, recessive, mode. This means, that the individual can be free of the disease (homozygote normal), affected (homozygous affected) or carrier (heterozygous).

Carriers may spread the mutation in a population without showing symptoms themselves. Because of this, it is extremely important to identify carriers correctly to prevent spreading of a mutation.

Severity of Disease

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Dog

Primary Glaucoma

Code H383
€ 47,80 (incl. 21% VAT)
€ 39,50 (excl. VAT)
Quantity