EIC (exercise-induced collapse) is a neuromuscular disorder, especially those dogs used for hunting and field trials. Research has identified the gene responsible for the condition known as EIC. A mutation in the canine dynamin 1 (DNM1) gene is very likely to be fundamentally responsible for EIC.
The syndrome of Exercise Induced Collapse (EIC) is manifested by muscle weakness and life-threatening collapse after intense exercise. Five to fifteen minutes of exercise causes dogs suffering from this condition to develop a wobbly gait, which soon progresses to a loss of control of the rear limbs. The symptoms may progress to all four limbs. Collapse episodes usually last for 10 minutes, and after 30 minutes there is often full recovery. The symptoms are occasionally fatal.
Test specific information
This test is patented in certain countries. We offer our clients two options for this test because we are not allowed to perform the test in our laboratory.
Firstly, the test can be ordered through a licensee of the patent owner. In this case, the patent owner requires that privacy sensitive information is provided. Per submitted sample a fully filled out form Form ‘Permission providing personal and animal data to patent owner ‘ is required.
As a second option, the test can be forwarded to a partner laboratory in non-patented territory.
Between these two options, a price difference is in place which is caused by the royalties costs on the test. The tests performed by both labs are technical identical.
The genetic factor is continuously present, and will always be visible.
Normally the result can be expected within 20 working days. This turn-around-time starts when both the sample and the fully filled-out and signed submission form have been received.
Location of disease or trait
The disease is present in muscle. Depending on the effect, degeneration of muscle may take place. Alternatively, recovery following exercise may be deteriorated.
This DNA test is available for the following breeds: Labrador Retriever, Chesapeake Bay Retriever, Curly-Coated Retriever, Australian Labradoodle. Additional information is available in the Frequently Asked Questions (FAQ).
For this DNA test we accept the following materials: Blood EDTA, Blood Heparin, Swab, Semen, Tissue. Please contact Dr. Van Haeringen Laboratorium if you wish to submit other material as listed.
An animal can be free and has in that situation two healthy alleles. When used in breeding this animal will not become ill due to the disease. It cannot spread the disease in the population.
An animal can be carrier and has in that situation one healthy and one disease allele. When used in breeding 50 percent of the offspring will receive the disease allele. Carriers will not become ill.
An animal can be affected and has in that situation two disease alleles. When used in breeding all offspring will also receive the disease allele. Affected will become ill.
This genetic factor is inherited in an autosomal, recessive, mode. This means, that the individual can be free of the disease (homozygote normal), affected (homozygous affected) or carrier (heterozygous).
Carriers may spread the mutation in a population without showing symptoms themselves. Because of this, it is extremely important to identify carriers correctly to prevent spreading of a mutation.
Severity of Disease