R306 FH4 mutation

Background

The search for homozygous haplotype deficiency (HHD) in large-scale genotype data is a strategy that allows for the identification of recessively inherited diseases. It was successfully applied to the Fleckvieh breed, where several disease related haplotypes could be determined. One of these is FH4 (Fleckvieh haplotype 4). FH4 was not found in a homozygous condition in the breed, suggesting a recessive embryonically lethal mutation. According to that expectation, insemination success was reduced in carrier matings. The causative mutation was detected in the SUGT1 gene which codes for SGT1. Impaired function of SGT1 inhibits the mitotic cell cycle leading to abortion.

Test specific information

-

Age

This disease leads to a reduction in the number of liveborn offspring. Depending on the disease, affected individuals may be stillborn or aborted.

Throughput

The turn-around-time of a test depends to a large extent on the logistics of sample transportation to the laboratory. After receiving the sample at the test location, you can normally expect the result within 10 working days. A longer delivery time applies to tests carried out by a Partner Lab.

Location of disease or trait

-

Breed dependence

This DNA test is available for the following breeds: Fleckvieh. Additional information is available in the Frequently Asked Questions (FAQ).

Sample type

For this DNA test we accept the following materials: Blood EDTA, Blood Heparin, Semen, Hair, Tissue. Please contact Dr. Van Haeringen Laboratorium if you wish to submit other material as listed.

Result

An animal can be free and has in that situation two healthy alleles. When used in breeding this animal will not become ill due to the disease. It cannot spread the disease in the population.

An animal can be carrier and has in that situation one healthy and one disease allele. When used in breeding 50 percent of the offspring will receive the disease allele. Carriers will not become ill.

An animal can be affected and has in that situation two disease alleles. When used in breeding all offspring will also receive the disease allele. Affected will become ill.

Inheritance

This genetic factor is inherited in an autosomal, recessive, mode. This means, that the individual can be free of the disease (homozygote normal), affected (homozygous affected) or carrier (heterozygous).

Carriers may spread the mutation in a population without showing symptoms themselves. Because of this, it is extremely important to identify carriers correctly to prevent spreading of a mutation.

Severity of Disease

-

Code R306

FH4 mutation

Test variant