Enterotoxigenic Escherichia coli (ETEC) is a disease causing type of bacteria that can easily spread among stable- and littermates. The ETEC can be classified based on different fimbriae types present on the surface of the bacteria, from which F4 (K88) and F18 are the most important subtypes. The fimbriae are used by the E. Coli to attach to the intestinal cells of the host and after adhesion the bacteria release enterotoxins and causes diarrhoea. The susceptibility of a host to the adhesion by the bacteria can be genetically determined.
The F4 fimbriae consist of lectins and two subtypes can be distinguished: F4ab and F4ac. The inheritance of both these subtypes is controlled by one single locus and this locus will be genetically tested.
Test specific information
Susceptibility of a host to ETEC-F4 can be genetically determined by this DNA test.
The genetic factor is continuously present, and will always be visible.
The Turnaround Time (TAT) depends on various factors, such as the shipment time of your sample to the test location, the test method(s) and whether the tests are performed completely or partially by a Partner Lab or Patent owner.
The TAT of tests performed at our facilities is normally 10 working days after receipt of the sample at the testing laboratory (VHL, VHP or Certagen). For tests performed by a Partner Laboratory (so-called "partner lab test") or patent owner, the TAT is at least 20 working days after receipt of your sample. Because the shipment time to our Partner Labs or patent owner may vary due to factors we cannot influence, the mentioned 20 working days are therefore an estimate.
Sometimes it is necessary to re-run your sample. We call this a retest. In that case, the TAT will of course be extended.
Location of disease or trait
For this test samples from all breeds are accepted.
For this DNA test we accept the following materials: Semen, Blood EDTA, Blood Heparin, Tissue. Please contact Dr. Van Haeringen Laboratorium if you wish to submit other material as listed.
An animal can be free and has in that situation two healthy alleles. When used in breeding this animal will not become ill due to the disease. It cannot spread the disease in the population.
An animal can be carrier and has in that situation one healthy and one disease allele. When used in breeding 50 percent of the offspring will receive the disease allele. Carriers will not become ill.
An animal can be affected and has in that situation two disease alleles. When used in breeding all offspring will also receive the disease allele. Affected will become ill.
This genetic factor is inherited in an autosomal, recessive, mode. This means, that the individual can be free of the disease (homozygote normal), affected (homozygous affected) or carrier (heterozygous).
Carriers may spread the mutation in a population without showing symptoms themselves. Because of this, it is extremely important to identify carriers correctly to prevent spreading of a mutation.
Severity of Disease