S306 Scrapie Goat susceptibility

Background

Transmissible spongiform encephalopathies (TSEs) are slowly progressive, fatal neurodegenerative diseases which affect a variety of mammalian species. In addition to causing neurodegeneration they are characterized by formation and accumulation of protease resistant prion protein mainly in the central nervous system. The development of scrapie in sheep is closely linked to polymorphisms in the host prion protein gene (PRNP). In goats, several studies also showed associations between amino acid substitutions in the caprine PRNP gene and the probability of scrapie infection. However, no complete resistance against scrapie infections has been identified in goats to date.

Test specific information

-

Age

The genetic factor is continuously present, and will always be visible.

Turn Around Time

The turn-around-time of a test depends to a large extent on the logistics of sample transportation to the laboratory. After receiving the sample at the test location, you can normally expect the result within 10 working days. A longer delivery time applies to tests carried out by a Partner Lab.

Location of disease or trait

This disease is present in the entire body, but causes main effects in the internal organs such as stomach, intestinal tract, liver and / or kidneys. In a number of cases, the disease affects one major internal organ.

Breed dependence

For this test samples from all breeds are accepted.

Sample type

For this DNA test we accept the following materials: Blood EDTA, Blood Heparin. Please contact Dr. Van Haeringen Laboratorium if you wish to submit other material as listed.

Result

Inheritance

The test for scrapie is based on a combination of genetic factors in one protein. The combination is inherited together.

Severity of Disease

-

Code S306

Scrapie Goat susceptibility

€ 43,44 (excl. VAT)