Background

Transmissible spongiform encephalopathies (TSEs) are slowly progressive, fatal neurodegenerative diseases which affect a variety of mammalian species. In addition to causing neurodegeneration they are characterized by formation and accumulation of protease resistant prion protein mainly in the central nervous system. The development of scrapie in sheep is closely linked to polymorphisms in the host prion protein gene (PRNP). In goats, several studies also showed associations between amino acid substitutions in the caprine PRNP gene and the probability of scrapie infection. However, no complete resistance against scrapie infections has been identified in goats to date.

Test specific information

-

Age

The genetic factor is continuously present, and will always be visible.

Turnaround time

The Turnaround Time (TAT) depends on various factors, such as the shipment time of your sample to the test location, the test method(s) and whether the tests are performed completely or partially by a Partner Lab or Patent owner.

The TAT of tests performed at our facilities is normally 10 working days after receipt of the sample at the testing laboratory (VHL, VHP or Certagen). For tests performed by a Partner Laboratory (so-called "partner lab test") or patent owner, the TAT is at least 20 working days after receipt of your sample. Because the shipment time to our Partner Labs or patent owner may vary due to factors we cannot influence, the mentioned 20 working days are therefore an estimate.

PLEASE NOTE
Sometimes it is necessary to re-run your sample. We call this a retest. In that case, the TAT will of course be extended.

Location of disease or trait

This disease is present in the entire body, but causes main effects in the internal organs such as stomach, intestinal tract, liver and / or kidneys. In a number of cases, the disease affects one major internal organ.

Breed dependence

For this test samples from all breeds are accepted.

Sample type

For this DNA test we accept the following materials: Blood EDTA, Blood Heparin. Please contact Dr. Van Haeringen Laboratorium if you wish to submit other material as listed.

Result

Inheritance

The test for scrapie is based on a combination of genetic factors in one protein. The combination is inherited together.

Severity of Disease

-