Background

The disease scrapie occurs in sheep due to a complex interaction between genetic factors and the environment. Genetic factors influencing scrapie have been identified in the PrP-gen. There are three amino acids (136, 154 and 171) at which the genetic variation is established in the DNA test. Results vary from sensitive to scrapie (V136) to resistant (R171).

Test specific information

SCRAPIE RESULT TABLE

Codon combination

    

Risk

ARR/ARR              Resistant
ARR/AHQ              Resistant
ARR/ARQ              Low risk
ARR/ARH              Low risk
AHQ/AHQ              Low risk
ARQ/AHQ              Low risk
AHQ/ARH              Low risk
ARH/ARH              Low risk
ARQ/ARH              Low risk
ARR/VRQ              Low risk
AHQ/VRQ              Low risk
ARQ/ARQ              High risk
ARQ/VRQ              Very high risk
ARH/VRQ              Very high risk
VRQ/VRQ              Very high risk

Source:
Baylis, M. et al., (2004). Risk of scrapie in British sheep of different prion protein genotype. Journal of General Virology, 85(9), 2735-2740.
European Commission: The policy of breeding and genotyping of sheep, i.e. the issue of whether sheep should be bred to be resistant to scrapie.

Age

The disease may show itself on different ages, in which it cannot be estimated when the first symptoms may show themselves. Differences may exist between littermates, and between breeds.

Turnaround time

The Turnaround Time (TAT) depends on various factors, such as the shipment time of your sample to the test location, the test method(s) and whether the tests are performed completely or partially by a Partner Lab or Patent owner.

The TAT of tests performed at our facilities is normally 10 working days after receipt of the sample at the testing laboratory (VHL, VHP or Certagen). For tests performed by a Partner Laboratory (so-called "partner lab test") or patent owner, the TAT is at least 20 working days after receipt of your sample. Because the shipment time to our Partner Labs or patent owner may vary due to factors we cannot influence, the mentioned 20 working days are therefore an estimate.

PLEASE NOTE
Sometimes it is necessary to re-run your sample. We call this a retest. In that case, the TAT will of course be extended.

Location of disease or trait

This disease leads to a loss of brain function.

Breed dependence

For this test samples from all breeds are accepted.

Sample type

For this DNA test we accept the following materials: Blood EDTA, Blood Heparin. Please contact Dr. Van Haeringen Laboratorium if you wish to submit other material as listed.

Result

The result of the scrapy test show the genetic variation at codons 136, 154 and 171.

Inheritance

The test for scrapie is based on a combination of genetic factors in one protein. The combination is inherited together.

Severity of Disease

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